Title

Probiotics in neonatology

RIS ID

89953

Publication Details

Hickey, L., Jacobs, S. E., Garland, S. M. & Wright, I. M. R. (2012). Probiotics in neonatology. Journal of Paediatrics and Child Health, 48 (9), 777-783.

Abstract

Probiotics are micro-organisms that confer health benefits on the host. Postulated mechanisms include: increasing resistance of the mucosal barrier to migration of bacteria and their toxins by strengthening intestinal cell junctions, modification of host response to microbial products, augmentation of immunoglobulin A mucosal responses, enhancement of enteral nutrition to inhibit the growth of pathogens; production of antimicrobial proteins; and competitive exclusion of potential pathogens. Published meta-analyses and systematic reviews report the effects of probiotics on important clinical outcomes in neonates. This paper will review the evidence for probiotic supplementation in neonatology, with a focus on preterm infants.

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Link to publisher version (DOI)

http://dx.doi.org/10.1111/j.1440-1754.2012.02508.x