Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?

Authors

Katrina Weston-Green, University of WollongongFollow
Xu-Feng Huang, University of WollongongFollow
Chao Deng, University of WollongongFollow

RIS ID

31528

Publication Details

Weston-Green, K., Huang, X. & Deng, C. (2010). Sensitivity of the female rat to olanzapine-induced weight gain - far from the clinic?. Schizophrenia Research, 116 (2-3), 299-300.

Abstract

Dear Editor, The recent paper by Chintoh and colleagues (2008) reporting olanzapine-induced dysfunction in glucose metabolism, enhanced visceral fat and reduced locomotor activity in female rats was highly interesting as it illustrated olanzapine’s ability to replicate aspects of metabolic dysfunction in the rodent model in a similar manner to the human scenario. However, contrary to previous reports in the rat and the clinic, the authors reported no change in body weight or food intake following olanzapine treatment, questioning the validity of the rat model.................