Title

High hydrostatic pressure effects investigated by neutron scattering on lipid multilamellar vesicles

RIS ID

85310

Publication Details

Trapp, M., Marion, J., Tehei, M., Deme, B., Gutberlet, T. & Peters, J. (2013). High hydrostatic pressure effects investigated by neutron scattering on lipid multilamellar vesicles. Physical Chemistry Chemical Physics, 15 (48), 20951-20956.

Abstract

The effects of high hydrostatic pressure on the structure and dynamics of model membrane systems were investigated using neutron scattering. Diffraction experiments show shifts of the pre- and main-phase transitions of multilamellar vesicles of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) to higher temperatures with increased pressure which are close to results observed previously by other techniques, namely (10.4 ± 1.0) K kbar−1 and (20.0 ± 0.5) K kbar−1 for the two transitions. Backscattering spectroscopy reveals that the mean square displacements in the liquid phase are about 10% smaller at 300 bar and about 20% smaller at 600 bar compared to atmospheric pressure, whereas in the gel phase below the main phase transition the mean square displacements show a smaller difference in the dynamics of the three pressure values within the studied pressure range.

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Link to publisher version (DOI)

http://dx.doi.org/10.1039/c3cp52762j