Title

Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice

RIS ID

37975

Publication Details

Huang, X., Yu, Y., Beck, E., South, T., Li, Y., Batterham, M., Tapsell, L. C. & Chen, J. 2011, 'Diet high in oat β-glucan activates the gut-hypothalamic (PYY3-36-NPY) axis and increases satiety in diet-induced obesity in mice', Molecular Nutrition and Food Research, vol. 55, no. 7, pp. 1118-1121.

Abstract

This study tested the effects of (1-3),(1-4) b-D-glucan from oats, on activation of the guthypothalamic (PYY3–36-NPY) axis, satiety, and weight loss in diet-induced obesity (DIO) mice. DIO mice were fed standard lab chow diets or varied doses of b-glucan for 6 weeks. Energy intake, satiety, body weight changes and peptide Y-Y3-36 (PYY3-36) were measured together with a satiety test and measurement of neuropeptide Y (NPY) mRNA expression in the hypothalamic arcuate nucleus (Arc). The average energy intake (-13%, po0.05) and body weight gain was lower with increasing b-glucan over 6 wk with acute suppression of energy intake over 4 h. The highest b-glucan diet significantly increased plasma PYY3-36, with suppression of Arc NPY mRNA.

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/mnfr.201100095