The components and anticancer activity of the volatile oil from Steblus asper

Authors

Weerachai Phutdhawong
Arwon Donchai
Jurgen Korth
Stephen G. Pyne, University of WollongongFollow
Porntipa Picha
Jarunya Ngamkham
Duang Buddhasukh

RIS ID

11494

Publication Details

Phutdhawong, W., Donchai, A., Korth, J., Pyne, S. G., Picha, P., Ngamkham, J. & Buddhasukh, D. (2004). The components and anticancer activity of the volatile oil from Steblus asper. Flavour and Fragrance Journal, 19 (5), 445-447.

Abstract

The volatile oil from fresh leaves of Streblus asper Lour. was isolated by hydrodistillation and analysed through a combination of gas chromatography with FID (GC–FID) and gas chromatography–mass spectrometry (GC–MS). The essential oil was obtained in 0.005% yield as a brown liquid. The major constituents of the volatile oil of S. asper were phytol (45.1%), α-farnesene (6.4%), trans-farnesyl acetate (5.8%), caryophyllene (4.9%) and trans-trans-α-farnesene (2.0%). In addition, the volatile oil showed significant anticancer activity (ED₅₀ << 30 µg/ml) from cytotoxicity primary screening tests with P388 (mouse lymphocytic leukaemia) cells but no significant antioxidant activity (IC₅₀ values of >>100 µg/ml) in a DPPH radical scavenging assay.