Phytochemical studies on Stemona burkillii Prain: Two new dihydrostemofoline alkaloids

Authors

Pitchaya Mungkornasawakul, University of Wollongong
Stephen G. Pyne, University of WollongongFollow
Araya Jatisatienr, Chiang Mai University
Wilford Lie, University of Wollongong
Alison T. Ung, University of Wollongong
Kritchaya Issakul, Chiang Mai University
Auntika Sawatwanich, Chiang Mai University
Damrat Supyen, Chiang Mai University
Chaiwat Jatisatienr, Chiang Mai University

RIS ID

11489

Publication Details

Mungkornasawakul, P., Pyne, S. G., Lie, W., Ung, A. T., Jatisatienr, A., Issakul, K., Sawatwanich, A. & Supyen, D. (2004). Phytochemical studies on Stemona burkillii Prain: Two new dihydrostemofoline alkaloids. Journal of Natural Products, 67 1740-1743.

Abstract

Two new dihydrostemofoline alkaloids, 11(S),12(R)-dihydrostemofoline (3) and stemoburkilline (4), along with stemofoline (1) and 2’-hydroxystemofoline (2) have been isolated from a root extract of Stemona burkillii Prain. The structure and relative configuration of (3) have been determined via spectroscopic data and from comparison with synthetic 11(S),12(S)-dihydrostemofoline (5). The configuration of the exo-cyclic alkene group in (4) is tentively assigned as (E) based upon mechanistic considerations.