Title

Synthesis of berberine-efflux pump inhibitor hybrid antibacterials

RIS ID

34532

Publication Details

Bremner, J. B. & Kelso, M. J. (2010). Synthesis of berberine-efflux pump inhibitor hybrid antibacterials. Synthetic Communications: an international journal for rapid communication of synthetic organic chem, 40 (23), 3561-3568.

Abstract

This article describes the compact synthesis of two isomeric dual-action hybrid antimicrobials where the 13-position of the antibacterial berberine has been linked via 3′-and 4′-methylene bridges to INF55 (5-nitro-2-phenylindole), an inhibitor of the bacterial NorA multidrug-resistance pump.

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Link to publisher version (DOI)

http://dx.doi.org/10.1080/00397910903457415