RIS ID
8014
Abstract
Streptococcus pyogenes (group A streptococcus) strains may express several distinct ®bronectinbinding proteins (FBPs) which are considered as major streptococcal adhesins. Of the FBPs, SfbI was shown in Šitro to promote internalization of the bacterium into host cells and has been implicated in persistence. In the tropical Northern Territory, where group A streptococcal infection is common, multiple genotypes of the organism were found among isolates from invasive disease cases and no dominant strains were observed. To determine whether any FBPs is associated with invasive disease propensity of S. pyogenes, we have screened streptococcal isolates from bacteraemic and necrotizing fasciitis patients and isolates from uncomplicated infections for genetic endowment of 4 FBPs. No difference was observed in the distribution of sfbII, fbp54 and sfbI between the blood isolates and isolates from uncomplicated infection. We conclude that the presence of sfbI does not appear to promote invasive diseases, despite its association with persistence. We also show a higher proportion of group A streptococcus strains isolated from invasive disease cases possess prtFII when compared to strains isolated from non-invasive disease cases. We suggest that S. pyogenes may recruit different FBPs for different purposes.
Included in
Life Sciences Commons, Physical Sciences and Mathematics Commons, Social and Behavioral Sciences Commons
Publication Details
This article was originally published as: Delvecchio, A, Currie, BJ, McArthur, JD, Walker, MJ & Sriprakash, KS, Streptococcus pyogenes prtFII, but not sfbI, sfbII or fbp54, is represented more frequently among invasive-disease isolates of tropical Australia, Epidemiology and Infection, 2002, 128(3), 391-396. Copyright 2002 Cambridge University Press. Journal information can be found here.