Title

Synthesis of alkaloid-like compounds via the bridging Ritter reaction

RIS ID

58093

Publication Details

Hemtasin, C., Ung, A. T., Kanokmedhakul, S., Kanokmedhakul, K., Bishop, R., Satraruji, T. & Bishop, D. (2012). Synthesis of alkaloid-like compounds via the bridging Ritter reaction. Monatshefte fuer Chemie: an international journal of chemistry, 143 (6), 955-963.

Abstract

Alkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s00706-012-0759-8