Synthesis of alkaloid-like compounds via the bridging Ritter reaction
RIS ID
58093
Abstract
Alkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents.
Publication Details
Hemtasin, C., Ung, A. T., Kanokmedhakul, S., Kanokmedhakul, K., Bishop, R., Satraruji, T. & Bishop, D. (2012). Synthesis of alkaloid-like compounds via the bridging Ritter reaction. Monatshefte fuer Chemie: an international journal of chemistry, 143 (6), 955-963.