Synthesis of alkaloid-like compounds via the bridging Ritter reaction

Authors

Chulida Hemtasin, Khon Kaen University
Alison T. Ung, University Of Technology SydneyFollow
Somdej Kanokmedhakul, Khon Kaen University
Kwanjai Kanokmedhakul, Khon Kaen University
Roger Bishop, University of New South Wales
Thanaphat Satraruji, University of Wollongong
David Bishop, University of Technology, Sydney

RIS ID

58093

Publication Details

Hemtasin, C., Ung, A. T., Kanokmedhakul, S., Kanokmedhakul, K., Bishop, R., Satraruji, T. & Bishop, D. (2012). Synthesis of alkaloid-like compounds via the bridging Ritter reaction. Monatshefte fuer Chemie: an international journal of chemistry, 143 (6), 955-963.

Abstract

Alkaloid-like compounds containing a benzo[c]azepine core structure were successfully prepared in three steps from 5H-dibenzo[a,d]cyclohepten-5-ol via the bridging Ritter reaction. Biological studies of these compounds revealed that some of them are AChE inhibitors and antimalarial agents.