The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki–Heck and Sonagashira coupling reactions

Authors

Uta Batenburg-Nguyen, University of WollongongFollow
Alison T. Ung, University of Wollongong
Stephen G. Pyne, University of WollongongFollow

RIS ID

30825

Publication Details

Batenburg-Nguyen, U. T., Ung, A. T. & Pyne, S. G. (2009). The synthesis of carbon linked bis-benzylisoquinolines using Mizoroki-Heck and Sonagashira coupling reactions. Tetrahedron, 65 (1), 318-327.

Abstract

Novel laudanosine dimers in which two laudanosine units are linked at C-2′ via a two or three-carbon linker (alkane, alkene or alkyne) have been prepared using palladium-catalysed cross-coupling reactions (Mizoroki–Heck and Sonagashira reactions). In one example, a second three-carbon linker between the two isoquinoline N-atoms was also present leading to a novel macrocyclic ring system.