Synthesis of 2′-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities

Authors

Uta Mbere-Nguyen, University of WollongongFollow
Alison T. Ung, University of Technology, Sydney
Stephen G. Pyne, University of WollongongFollow

RIS ID

33512

Publication Details

Mbere-Nguyen, U., Ung, A. T. & Pyne, S. G. (2010). Synthesis of 2'-aminoalkyl-1-benzylisoquinoline derivatives and medium sized ring analogues with mu opiod receptor binding activities. Tetrahedron, 66 (23), 4133-4143.

Abstract

Novel 2′-aminoalkyl-1-benzylisoquinoline compounds and medium size ring analogues have been prepared using reductive alkylation methods. Four of these analogues were tested for biological activity across 48 different CNS receptors and were showed to have binding activities at the mu opiod receptor.