Cephalosporin-3'-diazeniumdiolates:Targeted NO-donor prodrugs for dispersing bacterial biofilms
Biofilms are sessile communities of microbial cells contained within a self-produced exopolymeric matrix. Bacteria encased in biofilms exhibit upwards of 10–1000-fold higher resistance to biocides and traditional antibiotics than their planktonic counterparts (i.e. floating, unattached), and they are less susceptible to host immune defenses.[1, 2] Accordingly, chronic antimicrobial-tolerant bacterial infections are often biofilmbased (e.g. infections on indwelling medical devices and incurable Pseudomonas aeruginosa respiratory infections in cystic fibrosis (CF) sufferers). Currently there are few effective therapeutics for clearing biofilm-based infections, and a critical need exists for new agents and treatment strategies
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