Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry

Authors

Jennifer L. Beck, University of WollongongFollow
Rajesh Gupta, University of Wollongong
Thitima Urathamakul, University of WollongongFollow
Nyree L. Williamson, University of Wollongong
Margaret Sheil, University of WollongongFollow
Janice Aldrich-Wright, University of Western Sydney
Stephen F. Ralph, University of WollongongFollow

RIS ID

9957

Publication Details

Beck, J. L., Gupta, R., Urathamakul, T., Williamson, N. L., Sheil, M., Aldrich-Wright, J. & Ralph, S. F. (2003). Probing DNA selectivity of ruthenium metallointercalators using ESI mass spectrometry. Chemical Communications, (5), 626-627.

Abstract

ESI mass spectra show that up to five ruthenium molecules can bind non-covalently to double stranded 16mer DNA, and provide information on the relative affinity and DNA sequence selectivity of different ruthenium complexes.