RIS ID
33634
Abstract
ESI mass spectrometry was used to assess the binding of 13-substituted, 5-nitro-2-phenylindolyl- and 2-naphthalenyl-based berberine derivatives to inter- and intramolecular G-quadruplex DNA molecules. In contrast with the parent berberine, the compounds showed selectivity for quadruplex over duplex DNA and stabilised the quadruplex structure. They represent a new class of quadruplex DNA-selective ligands. © 2010 The Royal Society of Chemistry.
Included in
Life Sciences Commons, Physical Sciences and Mathematics Commons, Social and Behavioral Sciences Commons
Publication Details
Gornall, K., Samosorn, S., Tanwirat, B., Suksamrarn, A., Bremner, J. B., Kelso, M. J. & Beck, J. L. (2010). A mass spectrometric investigation of novel quadruplex DNA-selective berberine derivatives. Chemical Communications, 46 (35), 6602-6604.