Title

N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents

RIS ID

24416

Publication Details

Matesic, L., Locke, J., Bremner, J. B., Pyne, S. G., Skropeta, D., Ranson, M. & Vine, K. L. (2008). N-Phenethyl and N-naphthylmethyl isatins and analogues as in vitro cytotoxic agents. Bioorganic and Medicinal Chemistry, 16 (6), 3118-3124.

Abstract

Arange of N-phenethyl,N-phenacyl, and N-(1- and 2-naphthylmethyl) derivatives of 5,7-dibromoisatin 2 were prepared byN-alkylation reactions. Their activity against human monocyte-like histiocytic lymphoma (U937), leukemia (Jurkat), and breast carcinoma (MDA-MB-231) cell lines was assessed. The results allowed further development of structureactivity relationships. The compound 5,7-dibromo-N-(1-naphthylmethyl)-1H-indole-2,3-dione 5a was the most potent against U937 cells with an IC50 value of 0.19 microM.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.bmc.2007.12.026