Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release

Authors

Simon E. Moulton, University of WollongongFollow
Mark D. Imisides, University of WollongongFollow
Gordon G. Wallace, University of WollongongFollow
Roderick L. Shepherd, University of WollongongFollow

RIS ID

27125

Publication Details

Moulton, S. E., Imisides, M. D., Shepherd, R. L. & Wallace, G. G. (2008). Galvanic coupling conducting polymers to biodegradable Mg initiates autonomously powered drug release. Journal of Materials Chemistry, 18 3608-3613.

Abstract

Electrical stimulation to affect localised and controlled release of therapeutic drugs is becoming an attractive option in the treatment of acute diseases or chronic illnesses. Currently the materials developed for this technique rely on power sources to operate, making their progression from the laboratory to the biomedical marketplace problematic. To help alleviate this issue, we have demonstrated autonomously powered controlled release of a drug by exploiting the galvanic couple between biodegradable Mg alloy and a conducting organicpolymer. We also demonstrate the ability to control the rate of drug release by utilizing a range of biodegradable polymer coatings on the Mg alloy. Combination of the biodegradable Mg and conducting polymer provides a biocompatible platform for the autonomously controlled release of a drug at therapeutic levels.

Grant Number

ARC/FF0669110

Additional Grant Number

http://purl.org/au-research/grants/ARC/FF0669110