New results of CO global total column measurements using the Atmospheric Infrared Sounder (AIRS) aboard the Aqua satellite in comparison with Measurements of Pollution in the Troposphere (MOPITT) sensor aboard the Terra satellite are presented. Both data sets are validated using ground-based total column measurements in Russia and Australia. A quality parameter based on the Profile Percent A Priori values from the standard MOPITT product is introduced. AIRS data (version 4) for biomass burning events are in agreement or lower than both MOPITT and ground measurements, but CO bursts can be seen by AIRS in most cases. For the cases of low CO amounts in the Southern Hemisphere AIRS has a positive bias of ~3040% compared to MOPITT and ground truth. MOPITT data were used to estimate interannual variations of CO sources assuming a standard seasonal cycle for the main CO remover OH. A positive trend of CO global emissions for the second half of the year between 2000 and 2006 was found with no visible trend for the first half of the year. CO annual emission in 2006 was 184 + 40 Tg higher that that in 20002001. The monthly emission anomalies correlate well with an independently calculated Global Fire Emission Database (GFED2). Total carbon contribution from biomass burning in 1997, 1998 (both estimated by GFED2), and 2006 (according to MOPITT) were as high as (0.61) Pg C/year larger than in 2000, suggesting that fires can explain a substantial fraction of the interannual variability of CO2.