A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines
RIS ID
25500
Abstract
The reductive ring-opening of fullerenyldihydropyrrole yields ethyl N-benzhydryl fullerenyl[60]glycinate, which is deprotected to give ethyl fullerenylglycinate. The free amine is able to react with a variety of aldehydes and ketones in a Mannich-type process to produce 5-substituted and 5,5-disubstituted fulleroprolines and represents a versatile and general strategy to this class of compounds.
Publication Details
Thayumanavan, R., Hawkins, B. C., Keller, P. A., Pyne, S. G. and Ball, G. (2008). A mild and general method for the synthesis of 5-substituted and 5,5-disubstituted fulleroprolines. Organic Letters, 10 (6), 1315-1317.