Synthesis of some cyclic indolic peptoids as potential antibacterials

Authors

Vicki S. Au, University of Wollongong
John B. Bremner, University of WollongongFollow
Jonathan Coates, Avexa Ltd, Richmond, Victoria
Paul A. Keller, University of WollongongFollow
Stephen G. Pyne, University of WollongongFollow

RIS ID

16733

Publication Details

This article was originally published as: Au, VS, Bremner, JB, Coates, J, et al, Synthesis of some cyclic indolic peptoids as potential antibacterials, Tetrahedron, 2006, 62(40), 9373-9382. The original journal can be found here through Elsevier.

Abstract

The synthesis of cyclic peptoids containing an indole hydrophobic scaffold has been realised through the ring-closing metathesis of diallylated precursors. The precursors and their cyclic counterparts possessed poor antibacterial activity in contrast to previously reported cyclic peptoids containing hydrophobic scaffolds.