The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents

Authors

N. R. Yepuri, University of Wollongong
R. Haritakul, National Centre for Genetic Engineering and Biotechnology, Thailand
R. Griffith, University of Newcastle
S. P. Leach, University of Wollongong
Paul A. Keller, University of WollongongFollow

RIS ID

16736

Publication Details

This article was originally published as: Yepuri, NR, Haritakul, R, Griffith, R, Leach, SP & Keller, PA, The Synthesis and Testing of Arenearylpyrimidylmethanes (AAPM) as Anti-Malarial Agents, ChemMedchem, 2006, 1(7), 715-717. Copyright 2005 John Wiley & Sons. Journal information available here.

Abstract

The anti-malarial activity of the arenearylpyrimidylmethane (AAPM) class of compounds emerged from database searching of a pharmacophore. A new 2 step synthesis of the AAPM scaffold is reported and subsequent substitution yielded a short synthesis of the lead anti-malarial compound. The presence of atropisomerism in this class of compounds is also reported for the first time.