Title
Oxidative coupling of indoles using thallium(III) trifluoroacetate
Document Type
Journal Article
Publication Date
2008
Abstract
The oxidative coupling of polysubstituted electron-rich indoles mediated by thallium trifluoroacetate was found to be a facile, clean, and high yielding reaction. Indolic coupling sites were determined by the nature of the substituents present, with dimerisation at the indole 2-position being the dominant outcome. Indoles bearing two potential reaction sites with similar reactivity were additionally found to undergo heterocoupling.
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Publication Details
This article was originally published as Keller, PA, Yepuri, NR, Kelso, MJ, Mariani, M, Skelton, BW & White, AH, Oxidative coupling of indoles using thallium(III) trifluoroacetate, Tetrahedron, 64(33), 2008, 7787-7795. Original journal article available here