RIS ID
25504
Abstract
Pyrido- and pyrrolo[2,3-d]oxazoles can be conveniently prepared in high yield from the Ritter reaction of nitriles and in situ generated chiral cyclic N-acyliminium ions. cis-4-Hydroxy-5-acylaminopyrrolidines and cis-5-hydroxy-6-acylaminopiperidines can be readily obtained by acid hydrolysis of these bicyclic heterocyclic compounds, respectively.
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Publication Details
Morgan, I. R., Yazici, A., Pyne, S. G. & Skelton, B. W. (2008). Diastereoselective ritter reactions of chiral cyclic N-acyliminium ions: synthesis of pyrido- and pyrrolo [2,3-d] oxazoles and 4-hydroxy-5-N-acylaminopyrrolidines and 5-hydroxy-6-N-acylaminopiperidines. The Journal of Organic Chemistry, 73 (7), 2943-2946.