Title

Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones

RIS ID

22634

Publication Details

T. Murray, J. Kang, L. Astheimer, and W.E. Price, Tissue distribution of lignans in rats in response to diet, dose-response, and competition with isoflavones. Journal of Agricultural and Food Chemistry, 2007. 55(12): p. 4907-4912

Abstract

This paper investigates the occurrence and distribution of the lignan metabolites enterodiol (END) and enterolactone (ENL) and the isoflavone daidzein (DAID) in rat tissues using liquid chromatography - electrospray ionisation mass spectrometry (LC – ESI/MSn) following a variety of dietary regimes. Further, we examined the dose-response and distribution of END and ENL in liver, testes, prostate and lung, and investigated the effects of competition between lignans and isoflavones on metabolite distribution. In liver, testes, prostate & lung tissue, dose related increases in END concentration were observed. In the testes, the co-administration of 60 mg/kg SDG with 60 mg/kg isoflavones produced alterations in the resulting metabolite profile, causing increased END concentration and decreased DAID concentration. Results indicate lignan accumulation in tissues occurs, and co-administration of lignans with isoflavones affects the metabolite profile, with effects dependent on tissue type.

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Link to publisher version (DOI)

http://dx.doi.org/10.1021/jf070266q