Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas

Authors

Spyridon Miyakis, University of WollongongFollow
Triantafyllos L. Liloglou, Roy Castle International, UK
Shayne KearneyFollow
G Xinarianos, University of Liverpool
Demetrios A. Spandidos, Technical University of Crete
J K. Field, University of Liverpool

RIS ID

73252

Publication Details

Miyakis, S., Liloglou, T. L., Kearney, S., Xinarianos, G., Spandidos, D. A. and Field, J. (2003). Absence of mutations in the VHL gene but frequent loss of heterozygosity at 3p25-26 in non-small cell lung carcinomas. Lung Cancer, 39 (3), 273-277.

Abstract

In this study we have examined 79 primary non-small cell lung tumours for the presence of mutations of the VHL gene as well as for allelic imbalance at the gene surrounding loci. While allelic imbalance was found in 83% of specimens, frequently affecting the whole 3p25/p26 region, no mutations were detected in the VHL coding region. The fractional regional loss (FRL) was significantly higher in squamous cell carcinomas (0.746) than adenocarcinomas (0.493) (Wilcoxon P/0.002). This is the first investigation of the VHL gene mutational status in primary lung tumours. Our results indicate that mutation is not a common means of VHL inactivation in NSCLC.