Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child

Authors

David M. Wood, NHS Foundation, London
Alison H. Thomson, Western Infirmary, Glasgow, UK;
Matthew Lawes, Birmingham Children's Hospital, UK
Alison L. Jones, University of WollongongFollow
Paul I. Dargan, NHS Foundation, London

RIS ID

62752

Publication Details

Wood, D. M., Thomson, A. H., Lawes, M., Jones, A. L. & Dargan, P. I. (2005). Hepatocellular damage following therapeutic intravenous iron sucrose infusion in a child. Therapeutic Drug Monitoring, 27 (4), 405-408.

Abstract

The maximum tolerated single dose of intravenous iron infusion and iron pharmacokinetics are not known in children and not clear in adults. The case reported here is of a child given a large dose of intravenous iron sucrose (16 mg/kg) over 3 hours, who subsequently developed features of systemic iron toxicity. A TDM consultant discusses the case in the context of toxicokinetic analysis. Because the maximum tolerated dose and pharmacokinetics of intravenous iron preparations are not known, their use in both adults and children should still be undertaken with caution.