The Illawarra Health and Medical Research Institute is a partnership between the University of Wollongong and the South Eastern Sydney Illawarra Area Health Service. IHMRI's research focuses on health and medical issues that are common in the Illawarra region and is aimed at improving the health and well being of the local community. IHMRI's goal is to foster research collaboration through the IHMRI Research Network, creating a centre of excellence and innovation that represents the focal point of health and medical research in this region.
Papers from 2012
Cognitive and brain changes associated with ischaemic heart disease and heart failure, Osvaldo P. Almeida, Griselda J. Garrido, Christopher Etherton-Beer, Nicola Lautenschlager, Leonard F. Arnolda, and Leon Flicker
Proteogenomic analyses of Lingo-1 and the Nogo receptor in schizophrenia, J Andrews, K Newell, and F Fernandez
Guidelines for the management of absolute cardiovascular disease risk, Leonard F. Arnolda
Recent peritonitis associates with mortality among patients treated with peritoneal dialysis, Neil Boudville, Anna Kemp, Philip Clayton, Wai Lim, Sunil V. Badve, Carmel M. Hawley, Stephen P. McDonald, Kathryn J. Wiggins, Kym M. Bannister, Fiona G. Brown, and David W. Johnson
Factors associated with chronic kidney disease progression in Australian nephrology practices, Neil Boudville, Anna Kemp, Henry Moody, Robert G. Fassett, Eugenie Pedagogos, Craig Nelson, Helen Healy, George Mangos, Geoff Kirkland, Troy Kay, Paul Champion De Crespigny, David Hoffman, and David Waugh
The effect of trauma on expressive language impairment in borderline personality disorder, Phoebe Carter and Brin F. S Grenyer
Ovarian torsion in a 22-year old nulliparous woman, Hsiao-En Cindy Chen and Christos Georgiou
Prevention of obesity-associated colon cancer by (-)-epigallocatechin-3 gallate and curcumin, Jiezhong Chen
A review of cancer registry data in response to concerns about a possible excess of cancer associated with the emissions from the M5 East tunnel, Stephen Conaty, Darren Mayne, Kirsty Hope, and Mark Ferson
Generation of Pluripotent Stem Cells and their Developmental Potential, Brock J. Conley, Mark Denham, Martin F. Pera, and Mirella Dottori
γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins, Hartmut Cuny, Andrew de Faoite, Thuan G. Huynh, Takahiro Yasuda, Géza Berecki, and David J. Adams
Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage, Mark Denham, Chris Bye, Jessie Leung, Brock Conley, Lachlan H. Thompson, and Mirella Dottori
Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation, Mark Denham, Clare L. Parish, Bryan Leaw, Jordan Wright, Christopher Reid, Steven Petrou, Mirella Dottori, and Lachlan H. Thompson
Systemic arterial inflammation, measured with 18FDG-PET, is common amongst subjects with both recent and prior cerebrovascular disease, Christopher Etherton-Beer, Kathleen Potter, Nat Lenzo, David Blacker, Leonard F. Arnolda, Gaeme J. Hankey, and Ian B. Puddey
Effect of transfer delay on left ventricular function after primary PCI for ST elevation myocardial infarction, Ahmad Farshid, Leonard F. Arnolda, and Bruce Shadbolt
Homocysteine, grey matter and cognitive function in adults with cardiovascular disease, Andrew H. Ford, Griselda J. Garrido, Christopher Etherton-Beer, Nicola Lautenschlager, Leonard F. Arnolda, Leon Flicker, and Osvaldo P. Almeida
RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs, Aldo Franco, Shiva N. Kompella, Kalyana Akondi, Christian Melaun, Norelle L. Daly, Charles W. Luetje, Paul F. Alewood, David J. Craik, David J. Adams, and Frank Marí
Degradation of an old human protein: Age-dependent cleavage of yS-crystallin generates a peptide that binds to cell membranes*, Michael G. Friedrich, Jackson Lam, and Roger J. Truscott
Skepticism of de-torting large ovaries, C Georgiou
The possible mechanisms for β-glucans to prevent atherosclerotic lesions, Tiphaine Gislette, Kong-Nan Zhao, Wenyi Gu, and Jiezhong Chen
The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy, Niliksha Gunewardene, Mirella Dottori, and Bryony A. Nayagam
TNF-α promotes IFN-γ-Induced CD40 expression and antigen process in Myb-transformed hematological cells, Wenyi Gu, Jiezhong Chen, Lei Yang, and Kong-Nan Zhao
A cluster randomised controlled trial of vascular risk factor management in general practice, Mark F. Harris, Mahnaz Fanaian, Upali W. Jayasinghe, Megan Passey, Suzanne H. Mckenzie, G Davies, David Lyle, Rachel A. Laws, Heike Schuetze, and Qing Wan
A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides, Andrew Hollands, D Gonzalez, E Leire, Cortny A. Donald, Richard L. Gallo, Martina L. Sanderson-Smith, P Dorrestein, and Victor Nizet
Racemization of two proteins over our lifespan: deamidation of asparagine 76 in yS crystallin is greater in cataract than in normal lenses across the age range, M Y. Hooi, M Raftery, and Roger J. Truscott
Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells, Iman Jalilian, Mari Spildrejorde, Aine Seavers, Belinda L. Curtis, Jason D. McArthur, and Ronald Sluyter
Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease, Andrew M. Jenner, Guanghou Shui, M. R. Wenk, L. Lim, V. Jackson-Lewis, S. Przedborski, S. Kesavapany, A. X. H. Goh, M. Fivaz, and L. C. Wong
Cognitive phenotyping of amyloid precursor protein transgenic J20 mice, Tim Karl, Surabhi Bhatia, David Cheng, Woojin Scott Kim, and Brett Garner
Have increases in co-payments for medicines further burdened Australians in remote and disadvantaged areas?, Anna Kemp, John Glover, David B. Preen, Max Bulsara, James Semmens, and Elizabeth Roughead
The validity of prescription and other health service claims and self-report in identifying cases of invasive breast cancer in Australia, Anna Kemp, David B. Preen, Kris Rogers, Christobel Saunders, C D'Arcy Holman, Max Bulsara, Fran Boyle, and Elizabeth Roughead
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?, Oliver Knapp, Jeffrey R. McArthur, and David J. Adams
Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB, Oliver Knapp, Simon T. Nevin, Takahiro Yasuda, N Lawrence, Richard J. Lewis, and David J. Adams
Assessment of alternative water options in Adelaide: the MARSUO and optimal water resource mix projects, R Leonard and K S. Alexander
Genome-wide association study of multiplex schizophrenia pedigrees, Douglas F. Levinson, Jiaxin Shi, Kai Wang, Sang Oh, Brien Riley, Ann E. Pulver, Dieter B. Wildenauer, Claudine Laurent, Bryan J. Mowry, Pablo V. Gejman, Michael J. Owen, Kenneth S. Kendler, Gerald Nestadt, Sibylle G. Schwab, Jacques Mallet, Deborah Nertney, Alan R. Sanders, Nigel Williams, Brandon Wormley, Virginia K. Lasseter, Margot Albus, Stephanie Godard-Bauche, Madeline Alexander, Jubao Duan, Michael C. O'Donovan, Dermot Walsh, Anthony O'Neill, George N. Papadimitriou, Dimitris Dikeos, Wolfgang Maier, Bernard Lerer, Dominique Campion, David Cohen, Maurice Jay, Ayman Fanous, Peter Eichhammer, Jeremy M. Silverman, Nadine Norton, Nancy Zhang, Hakon Hakonarson, Cynthia Gao, Ami Citri, Mark Hansen, Stephan Ripke, Frank Dudbridge, and Peter A. Holmans
In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation, Shiang Y. Lim, Dong Guen Lee, Priyadharshini Sivakumaran, Duncan E. Crombie, John Slavin, Mirella Dottori, Brock Conley, Mark Denham, Jessie Leung, Richard Tee, Gregory J. Dusting, Alice Pebay, and Rodney J. Dilley
Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. McGregor, Jonathon Arnold, and Tim Karl
Non-viral generation of neural precursor-like cells from adult human fibroblasts, C Maucksch, E Firmin, C Butler-Munro, J Montgomery, Mirella Dottori, and Bronwen Connor
Software agents in clinical workflow, clinical guidelines and clinical trial medicine, Andrew Alexis Miller and Fiona Hegi-Johnson
Application of the water needs index: Can Tho City, Mekong Delta, Vietnam, Magnus Moglia, Luis E. Neumann, Kim S. Alexander, Mihn N. Nguyen, Ashok K. Sharma, Stephen Cook, Nguyen H. Trung, and Dinh D.A Tuan
Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain, I A. Napier, Harry Klimis, B K. Rycroft, A H. Jin, Paul F. Alewood, Leonid Motin, David J. Adams, and MacDonald J. Christie
Phospholipid peroxidation: Lack of effect of fatty acid pairing, Sarah E. Norris, Todd Mitchell, and Paul L. Else
Teaching psychiatry in a medical school environment: how is is different from Indian experience?, Nagesh B. Pai
Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function, Darshani B. Rupasinghe, Oliver Knapp, Linda V. Blomster, Annina B. Schmid, David J. Adams, Glenn F. King, and Marc J. Ruitenberg
Association of amygdala volumes with cortisol secretion in unipolar depressed patients, Anna Schuhmacher, Rainald Mossner, Frank Jessen, Lukas Scheef, Wolfgang Block, Anna C. Belloche, Leonhard Lennertz, Hanne Welper, Susanne Hofels, Ute Pfeiffer, Michael Wagner, Wolfgang Maier, Sibylle G. Schwab, and Astrid W. Zobel
Genetic modulation of the long-term effects of cannabis on brain structure, function and symptomatology, Nadia Solowij, Francesca Fernandez, Robin Murray, and Murat Yucel
Molecular signatures of long-lived proteins: Autolytic cleavage adjacent to serine residues, Shi-Ping (Jim) Su, Brian Lyons, M G. Friedrich, Jason D. McArthur, Xiuxian Song, D Xavier, Roger J. Truscott, and J A. Aquilina
Trends in long-term cardiovascular mortality and morbidity in men and women with heart failure of ischemic versus non-ischemic aetiology in Western Australia between 1990 and 2005, Tiew-Hwa Katherine Teng, Joseph Hung, Matthew Knuiman, Simon Stewart, Leonard F. Arnolda, Ian Jacobs, Michael Hobbs, F M. Sanfilippo, Elizabeth Geelhoed, and Judith Finn
Are we making the grade? The education of children and young people in out-of-home care, Michelle Townsend
Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?, Roger J. W Truscott, Jasminka Mizdrak, Michael G. Friedrich, Michelle Y. Hooi, Bryan Lyons, Joanne F. Jamie, Michael J. Davies, Phillip A. Wilmarth, and Larry L. David
Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels, Irina Vetter, Zoltan Dekan, Oliver Knapp, David J. Adams, Paul F. Alewood, and Richard J. Lewis
Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease, Jenny Wong, Brett Garner, Glenda M. Halliday, and John B.J Kwok
Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease, J Wong, M Higgins, G Halliday, and B Garner
Papers from 2011
Chapter 4: 'Water' - Resource Efficiency in Asia and the Pacific, Kim Alexander and James West
Evaluation of water needs index case studies, K S. Alexander, M Moglia, G Tjandraatmadja, M Nguyen, S Larson, N H. Trung, and R A. Barkey
Purification of immature neuronal cells from neural stem cell progeny, Hassan Azari, Geoffrey W. Osborne, Takahiro Yasuda, Mohammad G. Golmohammadi, Maryam Rahman, Loic P. Deleyrolle, Ebrahim Esfandiari, David J. Adams, Bjorn Scheffler, Dennis A. Steindler, and Brent A. Reynolds
Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2, Daria Bongiorno, Friderike Schuetz, Philip Poronnik, and David J. Adams
Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression, H Jane Brockmann, Astrid W. Zobel, Anna Schuhmacher, Marcel Daamen, Alexius Joe, Kim Biermann, Sibylle G. Schwab, Hans-Juergen Biersack, Wolfgang Maier, and Henning Boecker
Scanner uniformity improvements for radiochromic film analysis with matt reflectance backing, Ethan Butson, Hani Alnawaf, Peter K.N Yu, and Martin Butson
A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Jiezhong Chen, Zesong Li, Kwok Wah Chan, Liang Qiao, and Benjamin C. Y. Wong
Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin, M. Chen, Andrew M. Jenner, Z. F. Peng, A. J. Melendez, N. S. Cheung, J. Manikandan, and M. S. Choy
GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia, Xiangning Chen, G Lee, B S. Maher, A H. Fanous, J Chen, Zhongming Zhao, A Guo, E Van Den Oord, P F. Sullivan, and Sibylle G. Schwab
Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer, Blake J. Cochran, David Croucher, Sergei A. Lobov, Darren Saunders, and Marie Ranson
Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels, Norelle L. Daly, Brid P. Callaghan, Richard J. Clark, Simon T. Nevin, David J. Adams, and David J. Craik
Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding, Aline Dantas de Araujo, Brid P. Callaghan, Simon T. Nevin, Norelle L. Daly, David J. Craik, Melissa Moretta, Gene Hopping, MacDonald J. Christie, David J. Adams, and Paul F. Alewood
Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand, Melissa De Souza, Hayden Matthews, Jodi A. Lee, Marie Ranson, and Michael J. Kelso
Neural development in human embryonic stem cells-applications of lentiviral vectors, Mirella Dottori, Cheryl Tay, and Stephanie M. Hughes
Isoform-specific proteolysis of apolipoprotein-E in the brain, David A. Elliott, Kayan Tsoi, Sandra Holinkova, Sharon L. Chan, Woojin S. Kim, Glenda M. Halliday, Kerry-Anne Rye, and Brett Garner
Metformin therapy during pregnancy: good for the goose and good for the gosling too?, Denice S. Feig and Robert G. Moses
Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells, Caitlin E. Filby, Robert Williamson, Peter van Kooy, Alice Pebay, Mirella Dottori, Ngaire J. Elwood, and Faten Zaibak
The use of health impact assessment to determine the potential impact of an Australian urban development proposal on health and well-being, Susan Furber, Dian Tranter, Ben Harris-Roxas, Carolyn Dews, Erica Gray, Andy Goldie, Cate Wallace, Darren Mayne, and Sarah Thackway
Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation, Brett Garner, A Brown, Hanna Appelqvist, C Nilsson, K Kagedal, and K Ollinger
Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor, Reena Halai, Brid P. Callaghan, Norelle L. Daly, Richard J. Clark, David J. Adams, and David J. Craik
Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains, Leila Hejazi, Jason Wong, D. Cheng, Nicholas Proschogo, D. Ebrahimi, Brett Garner, and Anthony Don
Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice, Andrew M. Jenner, Runsheng Ruan, Jan Gruber, Francis Eng Hock Tay, and Yee Ting Wong
Nuclear microscopy of rat colon epithelial cells, Andrew M. Jenner, Frank Watt, Reshmi Rajendran, M. Ren, C. Udalagama, A. E. Rodrigues, and M. Ng
A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain, Harry Klimis, David J. Adams, Brid P. Callaghan, Simon T. Nevin, Paul F. Alewood, C W. Vaughan, C A. Mozar, and MacDonald J. Christie
Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma, Jodi A. Lee, Blake J. Cochran, Sergei A. Lobov, and Marie Ranson
Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation, Jun Liu, Huseyin Sumer, Jessie Leung, Kyle Upton, Mirella Dottori, Alice Pebay, and Paul J. Verma
Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients, Jun Liu, Paul J. Verma, Marguerite V. Evans-Galea, Martin B. Delatycki, Anna Michalska, Jessie Leung, Duncan E. Crombie, Joseph P. Sarsero, Robert Williamson, Mirella Dottori, and Alice Pebay
Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer, Sergei Lobov and Marie Ranson
Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization, Erica S. Lovelace, Sunithi Gunasekera, Charlotta Alvarmo, Richard J. Clark, Simon T. Nevin, Anton A. Grishin, David J. Adams, David J. Craik, and Norelle L. Daly
Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?, Hayden Matthews, Marie Ranson, and Michael J. Kelso
A community outbreak of cryptosporidiosis in Sydney associated with a public swimming facility: a case-control study, Darren J. Mayne, Kelly-Anne Ressler, Diane Smith, Gareth Hockey, Susan J. Botham, and Mark J. Ferson
Discussion of the enabling environments for decentralised water systems, Magnus Moglia, K S. Alexander, and Ashok K. Sharma
Perceived performance of decentralised water systems: a survey approach, Magnus Moglia, Ashok K. Sharma, Kim Alexander, and Aditi Mankad
3D mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM, Alex Perálvarez-Marín, Han Shen Tae, Philip G. Board, Marco G. Casarotto, Angela Dulhunty, and Montserrat Samsó
Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy, Marie Ranson
Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?, Helena Safavi-Hemami, William A. Siero, Zhihe Kuang, Nicholas A. Williamson, John A. Karas, Louise R. Page, David MacMillan, Brid P. Callaghan, Shiva N. Kompella, David J. Adams, Raymond Norton, and Anthony W. Purcell
Expression of PIP4K2A in Lymphocyte Cell Lines from a sample of schizophrenia patients with previous evidence for association, Llewellyn Saggers-Gray, Dieter B. Wildenauer, and Sibylle G. Schwab
PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder, Anna Schuhmacher, Rainald Mossner, Susanne Hofels, Ute Pfeiffer, Vera Guttenthaler, Michael Wagner, Sibylle G. Schwab, Wolfgang Maier, and Astrid W. Zobel
Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development, D Sinclair, M J. Webster, J Wong, and C S. Weickert
Cyclization of the intrinsically disordered a1Sdihydropyridine receptor II-III loop enhances secondary structure and in vitro function, Han Shen Tae, Yanfang Cui, Yamuna Karunasekara, Philip G. Board, Angela Dulhunty, and Marco G. Casarotto
Full length TrkB potentiates estrogen receptor alpha mediated transcription suggesting convergence of susceptibility pathways in schizophrenia, Jenny Wong, H G Woon, and Cynthia Shannon Weickert
Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice, Zhi-Qiang Xu, Ying Sun, Hong-Yun Li, Yoon Lim, Jin-Hua Zhong, and Xin-Fu Zhou
Codon usage roles in human papillomavirus, Kongnan Zhao and Jiezhong Chen
Papers from 2010
Water needs assessment: learning to deal with scale, subjectivity and high stakes, Kim S. Alexander, Magnus Moglia, and Craig Miller
Sustainable development in the uplands of lao PDR, Kim Suzanne Alexander, Joanne Millar, and Neil Lipscombe
Community management of onsite wastewater treatment systems- what they want in Mount Gambier, South Australia, K S. Alexander, K J. Levett, and J L. Vanderzalm
Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species, Matthew PG Barnett, Warren C. McNabb, Adrian L. Cookson, Shuotun Zhu, Marcus Davy, Bianca Knoch, Katie Nones, Alison J. Hodgkinson, and Nicole Roy
Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels, Géza Berecki, Leonid Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, C-I Anderson Wang, Melissa Moretta, Richard J. Lewis, Paul F. Alewood, MacDonald J. Christie, and David J. Adams