The Illawarra Health and Medical Research Institute is a partnership between the University of Wollongong and the South Eastern Sydney Illawarra Area Health Service. IHMRI's research focuses on health and medical issues that are common in the Illawarra region and is aimed at improving the health and well being of the local community. IHMRI's goal is to foster research collaboration through the IHMRI Research Network, creating a centre of excellence and innovation that represents the focal point of health and medical research in this region.

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Papers from 2012

Cognitive and brain changes associated with ischaemic heart disease and heart failure, Osvaldo P. Almeida, Griselda J. Garrido, Christopher Etherton-Beer, Nicola Lautenschlager, Leonard F. Arnolda, and Leon Flicker

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Proteogenomic analyses of Lingo-1 and the Nogo receptor in schizophrenia, J Andrews, K Newell, and F Fernandez

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Guidelines for the management of absolute cardiovascular disease risk, Leonard F. Arnolda

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Recent peritonitis associates with mortality among patients treated with peritoneal dialysis, Neil Boudville, Anna Kemp, Philip Clayton, Wai Lim, Sunil V. Badve, Carmel M. Hawley, Stephen P. McDonald, Kathryn J. Wiggins, Kym M. Bannister, Fiona G. Brown, and David W. Johnson

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Factors associated with chronic kidney disease progression in Australian nephrology practices, Neil Boudville, Anna Kemp, Henry Moody, Robert G. Fassett, Eugenie Pedagogos, Craig Nelson, Helen Healy, George Mangos, Geoff Kirkland, Troy Kay, Paul Champion De Crespigny, David Hoffman, and David Waugh

The effect of trauma on expressive language impairment in borderline personality disorder, Phoebe Carter and Brin F. S Grenyer

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Ovarian torsion in a 22-year old nulliparous woman, Hsiao-En Cindy Chen and Christos Georgiou

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Prevention of obesity-associated colon cancer by (-)-epigallocatechin-3 gallate and curcumin, Jiezhong Chen

A review of cancer registry data in response to concerns about a possible excess of cancer associated with the emissions from the M5 East tunnel, Stephen Conaty, Darren Mayne, Kirsty Hope, and Mark Ferson

Generation of Pluripotent Stem Cells and their Developmental Potential, Brock J. Conley, Mark Denham, Martin F. Pera, and Mirella Dottori

γ-Aminobutyric acid type B (GABAB) receptor expression is needed for inhibition of N-type (Cav2.2) calcium channels by analgesic α-conotoxins, Hartmut Cuny, Andrew de Faoite, Thuan G. Huynh, Takahiro Yasuda, Géza Berecki, and David J. Adams

Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage, Mark Denham, Chris Bye, Jessie Leung, Brock Conley, Lachlan H. Thompson, and Mirella Dottori

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Neurons derived from human embryonic stem cells extend long-distance axonal projections through growth along host white matter tracts after intra-cerebral transplantation, Mark Denham, Clare L. Parish, Bryan Leaw, Jordan Wright, Christopher Reid, Steven Petrou, Mirella Dottori, and Lachlan H. Thompson

Systemic arterial inflammation, measured with 18FDG-PET, is common amongst subjects with both recent and prior cerebrovascular disease, Christopher Etherton-Beer, Kathleen Potter, Nat Lenzo, David Blacker, Leonard F. Arnolda, Gaeme J. Hankey, and Ian B. Puddey

Effect of transfer delay on left ventricular function after primary PCI for ST elevation myocardial infarction, Ahmad Farshid, Leonard F. Arnolda, and Bruce Shadbolt

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Homocysteine, grey matter and cognitive function in adults with cardiovascular disease, Andrew H. Ford, Griselda J. Garrido, Christopher Etherton-Beer, Nicola Lautenschlager, Leonard F. Arnolda, Leon Flicker, and Osvaldo P. Almeida

RegIIA: an α4/7-conotoxin from the venom of Conus regius that potently blocks α3β4 nAChRs, Aldo Franco, Shiva N. Kompella, Kalyana Akondi, Christian Melaun, Norelle L. Daly, Charles W. Luetje, Paul F. Alewood, David J. Craik, David J. Adams, and Frank Marí

Degradation of an old human protein: Age-dependent cleavage of yS-crystallin generates a peptide that binds to cell membranes*, Michael G. Friedrich, Jackson Lam, and Roger J. Truscott

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Skepticism of de-torting large ovaries, C Georgiou

The possible mechanisms for β-glucans to prevent atherosclerotic lesions, Tiphaine Gislette, Kong-Nan Zhao, Wenyi Gu, and Jiezhong Chen

The Convergence of Cochlear Implantation with Induced Pluripotent Stem Cell Therapy, Niliksha Gunewardene, Mirella Dottori, and Bryony A. Nayagam

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TNF-α promotes IFN-γ-Induced CD40 expression and antigen process in Myb-transformed hematological cells, Wenyi Gu, Jiezhong Chen, Lei Yang, and Kong-Nan Zhao

A cluster randomised controlled trial of vascular risk factor management in general practice, Mark F. Harris, Mahnaz Fanaian, Upali W. Jayasinghe, Megan Passey, Suzanne H. Mckenzie, G Davies, David Lyle, Rachel A. Laws, Heike Schuetze, and Qing Wan

A bacterial pathogen co-opts host plasmin to resist killing by cathelicidin antimicrobial peptides, Andrew Hollands, D Gonzalez, E Leire, Cortny A. Donald, Richard L. Gallo, Martina L. Sanderson-Smith, P Dorrestein, and Victor Nizet

Racemization of two proteins over our lifespan: deamidation of asparagine 76 in yS crystallin is greater in cataract than in normal lenses across the age range, M Y. Hooi, M Raftery, and Roger J. Truscott

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Functional expression of the damage-associated molecular pattern receptor P2X7 on canine kidney epithelial cells, Iman Jalilian, Mari Spildrejorde, Aine Seavers, Belinda L. Curtis, Jason D. McArthur, and Ronald Sluyter

Lanosterol induces mitochondrial uncoupling and protects dopaminergic neurons from cell death in a model for Parkinson's disease, Andrew M. Jenner, Guanghou Shui, M. R. Wenk, L. Lim, V. Jackson-Lewis, S. Przedborski, S. Kesavapany, A. X. H. Goh, M. Fivaz, and L. C. Wong

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Cognitive phenotyping of amyloid precursor protein transgenic J20 mice, Tim Karl, Surabhi Bhatia, David Cheng, Woojin Scott Kim, and Brett Garner

Have increases in co-payments for medicines further burdened Australians in remote and disadvantaged areas?, Anna Kemp, John Glover, David B. Preen, Max Bulsara, James Semmens, and Elizabeth Roughead

The validity of prescription and other health service claims and self-report in identifying cases of invasive breast cancer in Australia, Anna Kemp, David B. Preen, Kris Rogers, Christobel Saunders, C D'Arcy Holman, Max Bulsara, Fran Boyle, and Elizabeth Roughead

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Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics?, Oliver Knapp, Jeffrey R. McArthur, and David J. Adams

Biophysical properties of Nav1.8/Nav1.2 chimeras and inhibition by μo-conotoxin MrVIB, Oliver Knapp, Simon T. Nevin, Takahiro Yasuda, N Lawrence, Richard J. Lewis, and David J. Adams

Assessment of alternative water options in Adelaide: the MARSUO and optimal water resource mix projects, R Leonard and K S. Alexander

Genome-wide association study of multiplex schizophrenia pedigrees, Douglas F. Levinson, Jiaxin Shi, Kai Wang, Sang Oh, Brien Riley, Ann E. Pulver, Dieter B. Wildenauer, Claudine Laurent, Bryan J. Mowry, Pablo V. Gejman, Michael J. Owen, Kenneth S. Kendler, Gerald Nestadt, Sibylle G. Schwab, Jacques Mallet, Deborah Nertney, Alan R. Sanders, Nigel Williams, Brandon Wormley, Virginia K. Lasseter, Margot Albus, Stephanie Godard-Bauche, Madeline Alexander, Jubao Duan, Michael C. O'Donovan, Dermot Walsh, Anthony O'Neill, George N. Papadimitriou, Dimitris Dikeos, Wolfgang Maier, Bernard Lerer, Dominique Campion, David Cohen, Maurice Jay, Ayman Fanous, Peter Eichhammer, Jeremy M. Silverman, Nadine Norton, Nancy Zhang, Hakon Hakonarson, Cynthia Gao, Ami Citri, Mark Hansen, Stephan Ripke, Frank Dudbridge, and Peter A. Holmans

In vivo tissue engineering chamber supports human induced pluripotent stem cell survival and rapid differentiation, Shiang Y. Lim, Dong Guen Lee, Priyadharshini Sivakumaran, Duncan E. Crombie, John Slavin, Mirella Dottori, Brock Conley, Mark Denham, Jessie Leung, Richard Tee, Gregory J. Dusting, Alice Pebay, and Rodney J. Dilley

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Distinct neurobehavioural effects of cannabidiol in transmembrane domain neuregulin 1 mutant mice, Leonora E. Long, Rose Chesworth, Xu-Feng Huang, Alexander Wong, Adena Spiro, Iain S. McGregor, Jonathon Arnold, and Tim Karl

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Non-viral generation of neural precursor-like cells from adult human fibroblasts, C Maucksch, E Firmin, C Butler-Munro, J Montgomery, Mirella Dottori, and Bronwen Connor

Software agents in clinical workflow, clinical guidelines and clinical trial medicine, Andrew Alexis Miller and Fiona Hegi-Johnson

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Application of the water needs index: Can Tho City, Mekong Delta, Vietnam, Magnus Moglia, Luis E. Neumann, Kim S. Alexander, Mihn N. Nguyen, Ashok K. Sharma, Stephen Cook, Nguyen H. Trung, and Dinh D.A Tuan

Intrathecal α-conotoxins Vc1.1, AuIB and MII acting on distinct nicotinic receptor subtypes reverse signs of neuropathic pain, I A. Napier, Harry Klimis, B K. Rycroft, A H. Jin, Paul F. Alewood, Leonid Motin, David J. Adams, and MacDonald J. Christie

Phospholipid peroxidation: Lack of effect of fatty acid pairing, Sarah E. Norris, Todd Mitchell, and Paul L. Else

Teaching psychiatry in a medical school environment: how is is different from Indian experience?, Nagesh B. Pai

Localization of Nav 1.7 in the normal and injured rodent olfactory system indicates a critical role in olfaction, pheromone sensing and immune function, Darshani B. Rupasinghe, Oliver Knapp, Linda V. Blomster, Annina B. Schmid, David J. Adams, Glenn F. King, and Marc J. Ruitenberg

Association of amygdala volumes with cortisol secretion in unipolar depressed patients, Anna Schuhmacher, Rainald Mossner, Frank Jessen, Lukas Scheef, Wolfgang Block, Anna C. Belloche, Leonhard Lennertz, Hanne Welper, Susanne Hofels, Ute Pfeiffer, Michael Wagner, Wolfgang Maier, Sibylle G. Schwab, and Astrid W. Zobel

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Genetic modulation of the long-term effects of cannabis on brain structure, function and symptomatology, Nadia Solowij, Francesca Fernandez, Robin Murray, and Murat Yucel

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Molecular signatures of long-lived proteins: Autolytic cleavage adjacent to serine residues, Shi-Ping (Jim) Su, Brian Lyons, M G. Friedrich, Jason D. McArthur, Xiuxian Song, D Xavier, Roger J. Truscott, and J A. Aquilina

Trends in long-term cardiovascular mortality and morbidity in men and women with heart failure of ischemic versus non-ischemic aetiology in Western Australia between 1990 and 2005, Tiew-Hwa Katherine Teng, Joseph Hung, Matthew Knuiman, Simon Stewart, Leonard F. Arnolda, Ian Jacobs, Michael Hobbs, F M. Sanfilippo, Elizabeth Geelhoed, and Judith Finn

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Are we making the grade? The education of children and young people in out-of-home care, Michelle Townsend

Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine?, Roger J. W Truscott, Jasminka Mizdrak, Michael G. Friedrich, Michelle Y. Hooi, Bryan Lyons, Joanne F. Jamie, Michael J. Davies, Phillip A. Wilmarth, and Larry L. David

Isolation, characterization and total regioselective synthesis of the novel μo-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels, Irina Vetter, Zoltan Dekan, Oliver Knapp, David J. Adams, Paul F. Alewood, and Richard J. Lewis

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Srp20 regulates TrkB pre-mRNA splicing to generate TrkB-Shc transcripts with implications for Alzheimer's disease, Jenny Wong, Brett Garner, Glenda M. Halliday, and John B.J Kwok

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Amyloid beta selectively modulates neuronal TrkB alternative transcript expression with implications for Alzheimer's disease, J Wong, M Higgins, G Halliday, and B Garner

Papers from 2011

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Chapter 4: 'Water' - Resource Efficiency in Asia and the Pacific, Kim Alexander and James West

Evaluation of water needs index case studies, K S. Alexander, M Moglia, G Tjandraatmadja, M Nguyen, S Larson, N H. Trung, and R A. Barkey

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Purification of immature neuronal cells from neural stem cell progeny, Hassan Azari, Geoffrey W. Osborne, Takahiro Yasuda, Mohammad G. Golmohammadi, Maryam Rahman, Loic P. Deleyrolle, Ebrahim Esfandiari, David J. Adams, Bjorn Scheffler, Dennis A. Steindler, and Brent A. Reynolds

Regulation of voltage-gated ion channels in excitable cells by the ubiquitin ligases Nedd4 and Nedd4-2, Daria Bongiorno, Friderike Schuetz, Philip Poronnik, and David J. Adams

Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression, H Jane Brockmann, Astrid W. Zobel, Anna Schuhmacher, Marcel Daamen, Alexius Joe, Kim Biermann, Sibylle G. Schwab, Hans-Juergen Biersack, Wolfgang Maier, and Henning Boecker

Scanner uniformity improvements for radiochromic film analysis with matt reflectance backing, Ethan Butson, Hani Alnawaf, Peter K.N Yu, and Martin Butson

A possible role of cIAP2 in Helicobacter pylori-associated gastric cancer, Jiezhong Chen, Zesong Li, Kwok Wah Chan, Liang Qiao, and Benjamin C. Y. Wong

Up-regulation of endoplasmic reticulum stress-related genes during the early phase of treatment of cultured cortical neurons by the proteasomal inhibitor lactacystin, M. Chen, Andrew M. Jenner, Z. F. Peng, A. J. Melendez, N. S. Cheung, J. Manikandan, and M. S. Choy

GWA study data mining and independent replication identify cardiomyopathy-associated 5 (CMYA5) as a risk gene for schizophrenia, Xiangning Chen, G Lee, B S. Maher, A H. Fanous, J Chen, Zhongming Zhao, A Guo, E Van Den Oord, P F. Sullivan, and Sibylle G. Schwab

Dependence on Endocytic Receptor Binding via a Minimal Binding Motif Underlies the Differential Prognostic Profiles of SerpinE1 and SerpinB2 in Cancer, Blake J. Cochran, David Croucher, Sergei A. Lobov, Darren Saunders, and Marie Ranson

Structure and activity of α-conotoxin PeIA at nicotinic acetylcholine receptor subtypes and GABAB receptor-coupled N-type calcium channels, Norelle L. Daly, Brid P. Callaghan, Richard J. Clark, Simon T. Nevin, David J. Adams, and David J. Craik

Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding, Aline Dantas de Araujo, Brid P. Callaghan, Simon T. Nevin, Norelle L. Daly, David J. Craik, Melissa Moretta, Gene Hopping, MacDonald J. Christie, David J. Adams, and Paul F. Alewood

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Small molecule antagonists of the urokinase (uPA): urokinase receptor (uPAR) interaction with high reported potencies show only weak effects in cell-based competition assays employing the native uPAR ligand, Melissa De Souza, Hayden Matthews, Jodi A. Lee, Marie Ranson, and Michael J. Kelso

Neural development in human embryonic stem cells-applications of lentiviral vectors, Mirella Dottori, Cheryl Tay, and Stephanie M. Hughes

Isoform-specific proteolysis of apolipoprotein-E in the brain, David A. Elliott, Kayan Tsoi, Sandra Holinkova, Sharon L. Chan, Woojin S. Kim, Glenda M. Halliday, Kerry-Anne Rye, and Brett Garner

Metformin therapy during pregnancy: good for the goose and good for the gosling too?, Denice S. Feig and Robert G. Moses

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Stimulation of Activin A/Nodal signaling is insufficient to induce definitive endoderm formation of cord blood-derived unrestricted somatic stem cells, Caitlin E. Filby, Robert Williamson, Peter van Kooy, Alice Pebay, Mirella Dottori, Ngaire J. Elwood, and Faten Zaibak

The use of health impact assessment to determine the potential impact of an Australian urban development proposal on health and well-being, Susan Furber, Dian Tranter, Ben Harris-Roxas, Carolyn Dews, Erica Gray, Andy Goldie, Cate Wallace, Darren Mayne, and Sarah Thackway

Attenuation of the lysosomal death pathway by lysosomal cholesterol accumulation, Brett Garner, A Brown, Hanna Appelqvist, C Nilsson, K Kagedal, and K Ollinger

Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABAB receptor, Reena Halai, Brid P. Callaghan, Norelle L. Daly, Richard J. Clark, David J. Adams, and David J. Craik

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Mass and relative elution time profiling: Two-dimensional analysis of sphingolipids in Alzheimer's disease brains, Leila Hejazi, Jason Wong, D. Cheng, Nicholas Proschogo, D. Ebrahimi, Brett Garner, and Anthony Don

Chronic resveratrol intake reverses pro-inflammatory cytokine profile and oxidative DNA damage in ageing hybrid mice, Andrew M. Jenner, Runsheng Ruan, Jan Gruber, Francis Eng Hock Tay, and Yee Ting Wong

Nuclear microscopy of rat colon epithelial cells, Andrew M. Jenner, Frank Watt, Reshmi Rajendran, M. Ren, C. Udalagama, A. E. Rodrigues, and M. Ng

A novel mechanism of inhibition of high-voltage activated calcium channels by α-conotoxins contributes to relief of nerve injury-induced neuropathic pain, Harry Klimis, David J. Adams, Brid P. Callaghan, Simon T. Nevin, Paul F. Alewood, C W. Vaughan, C A. Mozar, and MacDonald J. Christie

Forty Years Later and the Role of Plasminogen Activator Inhibitor Type 2/SERPINB2 Is Still an Enigma, Jodi A. Lee, Blake J. Cochran, Sergei A. Lobov, and Marie Ranson

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Late passage human fibroblasts induced to pluripotency are capable of directed neuronal differentiation, Jun Liu, Huseyin Sumer, Jessie Leung, Kyle Upton, Mirella Dottori, Alice Pebay, and Paul J. Verma

Generation of Induced Pluripotent Stem Cell Lines from Friedreich Ataxia Patients, Jun Liu, Paul J. Verma, Marguerite V. Evans-Galea, Martin B. Delatycki, Anna Michalska, Jessie Leung, Duncan E. Crombie, Joseph P. Sarsero, Robert Williamson, Mirella Dottori, and Alice Pebay

Molecular competition between plasminogen activator inhibitors type -1 and -2 for urokinase: implications for cellular proteolysis and adhesion in cancer, Sergei Lobov and Marie Ranson

Stabilization of α-conotoxin AuIB: influences of disulfide connectivity and backbone cyclization, Erica S. Lovelace, Sunithi Gunasekera, Charlotta Alvarmo, Richard J. Clark, Simon T. Nevin, Anton A. Grishin, David J. Adams, David J. Craik, and Norelle L. Daly

Anti-tumour/metastasis effects of the potassium-sparing diuretic amiloride: An orally active anti-cancer drug waiting for its call-of-duty?, Hayden Matthews, Marie Ranson, and Michael J. Kelso

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A community outbreak of cryptosporidiosis in Sydney associated with a public swimming facility: a case-control study, Darren J. Mayne, Kelly-Anne Ressler, Diane Smith, Gareth Hockey, Susan J. Botham, and Mark J. Ferson

Discussion of the enabling environments for decentralised water systems, Magnus Moglia, K S. Alexander, and Ashok K. Sharma

Perceived performance of decentralised water systems: a survey approach, Magnus Moglia, Ashok K. Sharma, Kim Alexander, and Aditi Mankad

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3D mapping of the SPRY2 domain of ryanodine receptor 1 by single-particle cryo-EM, Alex Perálvarez-Marín, Han Shen Tae, Philip G. Board, Marco G. Casarotto, Angela Dulhunty, and Montserrat Samsó

Editorial: The Plasminogen Activation System in Pathology: Use in Prognosis and Therapy, Marie Ranson

Embryonic toxin expression in the cone snail Conus victoriae: primed to kill or divergent function?, Helena Safavi-Hemami, William A. Siero, Zhihe Kuang, Nicholas A. Williamson, John A. Karas, Louise R. Page, David MacMillan, Brid P. Callaghan, Shiva N. Kompella, David J. Adams, Raymond Norton, and Anthony W. Purcell

Expression of PIP4K2A in Lymphocyte Cell Lines from a sample of schizophrenia patients with previous evidence for association, Llewellyn Saggers-Gray, Dieter B. Wildenauer, and Sibylle G. Schwab

PCLO rs2522833 modulates HPA system response to antidepressant treatment in major depressive disorder, Anna Schuhmacher, Rainald Mossner, Susanne Hofels, Ute Pfeiffer, Vera Guttenthaler, Michael Wagner, Sibylle G. Schwab, Wolfgang Maier, and Astrid W. Zobel

Dynamic molecular and anatomical changes in the glucocorticoid receptor in human cortical development, D Sinclair, M J. Webster, J Wong, and C S. Weickert

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Cyclization of the intrinsically disordered a1Sdihydropyridine receptor II-III loop enhances secondary structure and in vitro function, Han Shen Tae, Yanfang Cui, Yamuna Karunasekara, Philip G. Board, Angela Dulhunty, and Marco G. Casarotto

Full length TrkB potentiates estrogen receptor alpha mediated transcription suggesting convergence of susceptibility pathways in schizophrenia, Jenny Wong, H G Woon, and Cynthia Shannon Weickert

Endogenous proBDNF is a negative regulator of migration of cerebellar granule cells in neonatal mice, Zhi-Qiang Xu, Ying Sun, Hong-Yun Li, Yoon Lim, Jin-Hua Zhong, and Xin-Fu Zhou

Codon usage roles in human papillomavirus, Kongnan Zhao and Jiezhong Chen

Papers from 2010

Water needs assessment: learning to deal with scale, subjectivity and high stakes, Kim S. Alexander, Magnus Moglia, and Craig Miller

Sustainable development in the uplands of lao PDR, Kim Suzanne Alexander, Joanne Millar, and Neil Lipscombe

Community management of onsite wastewater treatment systems- what they want in Mount Gambier, South Australia, K S. Alexander, K J. Levett, and J L. Vanderzalm

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Changes in colon gene expression associated with increased colon inflammation in interleukin-10 gene-deficient mice inoculated with Enterococcus species, Matthew PG Barnett, Warren C. McNabb, Adrian L. Cookson, Shuotun Zhu, Marcus Davy, Bianca Knoch, Katie Nones, Alison J. Hodgkinson, and Nicole Roy

Analgesic ω-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels, Géza Berecki, Leonid Motin, A Haythornthwaite, S Vink, P Bansal, R Drinkwater, C-I Anderson Wang, Melissa Moretta, Richard J. Lewis, Paul F. Alewood, MacDonald J. Christie, and David J. Adams