Title

Annexin A6 regulates interleukin-2-mediated T-cell proliferation

RIS ID

107233

Publication Details

Cornely, R., Pollock, A. H., Rentero, C., Norris, S. E., Alvarez-Guaita, A., Grewal, T., Mitchell, T., Enrich, C., Moss, S. E., Parton, R. G., Rossy, J. & Gaus, K. (2016). Annexin A6 regulates interleukin-2-mediated T-cell proliferation. Immunology and Cell Biology, 94 (6), 543-553.

Abstract

Annexin A6 (AnxA6) has been implicated in cell signalling by contributing to the organisation of the plasma membrane. Here we examined whether AnxA6 regulates signalling and proliferation in T cells. We used a contact hypersensitivity model to immune challenge wild-type (WT) and AnxA6−/− mice and found that the in vivo proliferation of CD4+ T cells, but not CD8+ T cells, was impaired in AnxA6−/− relative to WT mice. However, T-cell migration and signalling through the T-cell receptor ex vivo was similar between T cells isolated from AnxA6−/− and WT mice. In contrast, interleukin-2 (IL-2) signalling was reduced in AnxA6−/− compared with WT T cells. Further, AnxA6-deficient T cells had reduced membrane order and cholesterol levels. Taken together, our data suggest that AnxA6 regulates IL-2 homeostasis and sensitivity in T cells by sustaining a lipid raft-like membrane environment.

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Link to publisher version (DOI)

http://dx.doi.org/10.1038/icb.2016.15