Title

C-FOS expression in central cardiovascular pathways

RIS ID

109233

Publication Details

Minson, J. B., Suzuki, S., Llewellyn-Smith, I. J., Pilowsky, P. M., Arnolda, L. F. & Chalmers, J. P. (1995). C-FOS expression in central cardiovascular pathways. Clinical and Experimental Hypertension, 17 (1-2), 67-79.

Abstract

Injection of muscimol in the caudal ventrolateral medulla increases blood pressure and stimulates neuronal c-fos expression in the rostral ventral medulla (RVM). The blockade of c-fos expression in the RVM by antisense oligonucleotides attenuates the blood pressure response to this muscimol-induced disinhibition of the RVM and also reduces resting blood pressure. The results suggest that cardiovascular neurons in the RVM express c-fos and that the basal and stimulated expression of the c-fos gene is important in the central regulation of blood pressure.

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Link to publisher version (DOI)

http://dx.doi.org/10.3109/10641969509087055