Title

Insights into the subunit arrangement and diversity of paradoxin and taipoxin

RIS ID

105424

Publication Details

Harrison, J. A. & Aquilina, J. Andrew. (2016). Insights into the subunit arrangement and diversity of paradoxin and taipoxin. Toxicon, 112 45-50.

Abstract

Paradoxin and taipoxin are neurotoxic phospholipases from the inland and coastal species of Australian taipan. Despite their relatively high sequence homology of 70% and 84% for the acidic and basic chains respectively, they differ substantially in reported assays of neurotoxicity. This study provides the first characterisation of paradoxin, which like taipoxin, is a trimer at physiological pH. More broadly, these toxins were found to be composed of a more diverse range of subunits than previously recognised, including newly discovered γTPx isoforms, which give rise to an additional, major conformation of TPx.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.toxicon.2016.01.054