Title

Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons

RIS ID

107748

Publication Details

Burman, K. J., McKitrick, D. J., Minson, J. B., West, A., Arnolda, L. F. & Llewellyn-Smith, I. J. (2001). Neurokinin-1 receptor immunoreactivity in hypotension sensitive sympathetic preganglionic neurons. Brain Research, 915 (2), 238-243.

Abstract

Substance P activation of neurokinin-1 (NK1) receptors on spinal sympathetic preganglionic neurons (SPN) influences blood pressure. We identified SPN likely to subserve the baroreceptor reflex and established if these neurons showed NK1 receptor-immunoreactivity. Nitroprusside (NP) infusion or inferior vena cava (IVC) constriction activated similar numbers of SPN. Of these, about 40% were NK1 receptor-immunoreactive after NP infusion, but only about 20% were NK1 receptor-immunoreactive after IVC constriction. The distribution of Fos/NK1 receptor SPN suggested that substance P may preferentially target sympathoadrenal SPN.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/S0006-8993(01)02907-9