The engineering of an orally active conotoxin for the treatment of neuropathic pain
RIS ID
105274
Abstract
From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.
Publication Details
Clark, R. J., Jensen, J., Nevin, S. T., Callaghan, B. P., Adams, D. J. & Craik, D. J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie International Edition, 49 (37), 6545-6548.