Title

The engineering of an orally active conotoxin for the treatment of neuropathic pain

RIS ID

105274

Publication Details

Clark, R. J., Jensen, J., Nevin, S. T., Callaghan, B. P., Adams, D. J. & Craik, D. J. (2010). The engineering of an orally active conotoxin for the treatment of neuropathic pain. Angewandte Chemie International Edition, 49 (37), 6545-6548.

Abstract

From killers to curers: Peptides from cone snail venoms are potential therapeutic agents for the treatment of neuropathic pain. Unfortunately, these peptides suffer from the disadvantage of short biological half-lives and poor activity when taken orally. A new orally active conotoxin was developed to solve these problems.

Please refer to publisher version or contact your library.

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1002/anie.201000620