Title

Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding

RIS ID

105259

Publication Details

de Araujo, A. Dantas., Callaghan, B., Nevin, S. T., Daly, N. L., Craik, D. J., Moretta, M., Hopping, G., Christie, M. J., Adams, D. J. & Alewood, P. F. (2011). Total synthesis of the analgesic conotoxin MrVIB through selenocysteine-assisted folding. Angewandte Chemie International Edition, 50 (29), 6527-6529.

Abstract

Secs for your folding problems: Selenocysteine (Sec) residues were used to drive the folding of conotoxin MrVIB, a previously "unfoldable" miniprotein with therapeutic potential (see picture). This simple strategy should generally facilitate the folding of peptides and proteins with multiple disulfide bonds.

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Link to publisher version (DOI)

http://dx.doi.org/10.1002/anie.201101642