Title

Regulation of alpha-synuclein expression by liver X receptor ligands in vitro

RIS ID

39037

Publication Details

Cheng, D., Kim, W. & Garner, B. (2008). Regulation of alpha-synuclein expression by liver X receptor ligands in vitro. NeuroReport, 19 (17), 1685-1689.

Abstract

Alpha-synuclein is a lipid-binding protein expressed in neurons and oligodendrocytes which is increased in Parkinson's disease. We identified two putative liver X receptor (LXR) response elements in the human oc-synuclein gene and used synthetic (TO901317, GW3695) and physiological (27-hydroxycholesterol) LXR activators to assess regulation of α-synuclein. LXR ligands upregulated α-synuclein m RNA by two-five-fold in human SK-N-SH neurons and three-six-fold in human MO3.13 oligodendrocytes. Significant 50% to four-fold induction of α-synuclein protein was also detected. Under these conditions, m RNA for LXR-responsive gene ABCAI was significantly upregulated 15-40-fold and 5-25-fold in neurons and oligodendrocytes, respectively. LXR may, therefore, contribute to the regulation of α-synuclein expression in neurons and oligodendrocytes. © 2008 Wolters Kluwer Health | Lippincott Williams & Wilkins.

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Link to publisher version (DOI)

http://dx.doi.org/10.1097/WNR.0b013e32831578b2