IFN-γ promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host
RIS ID
49831
Abstract
Ags characterizing tumors or chronic viral infection are generally presented to the host immune system before specific immunotherapy is initiated, and consequent generation of regulatory CD4+ T cells can inhibit induction of desired effector CD8 T cell responses. IL-10 produced in response to ongoing Ag exposure inhibits generation of CD8 T cells in an Ag-experienced host. We now show that this IL-10 is produced by Ag experienced CD4+ glucocorticoid-induced tumor necrosis factor receptor+ T cells that also secrete IFN-γ upon antigenic stimulation, that IL-10 secretion by these cells is enhanced through IFN-γ signaling, and, unexpectedly, that IFN-γ signaling is required for inhibition of generation of Ag-specific CD8 T cell responses in an Ag-experienced host. Systemic inhibition of both IL-10 and IFN-γ at the time of immunization may therefore facilitate induction of effective immunotherapeutic responses against tumor specific and viral Ags.
Publication Details
Liu, X., Leerberg, J., MacDonald, K., Leggatt, G. R. & Frazer, I. H. (2009). IFN-¿ promotes generation of IL-10 secreting CD4+ T cells that suppress generation of CD8 responses in an antigen-experienced host. Journal of Immunology, 183 (1), 51-58.