Title

Arthropod toxins acting on neuronal potassium channels

RIS ID

116810

Publication Details

Jimenez-Vargas, J., Possani, L. D. & Luna-Ramirez, K. (2017). Arthropod toxins acting on neuronal potassium channels. Neuropharmacology, 127 139-160.

Abstract

Arthropod venoms are a rich mixture of biologically active compounds exerting different physiological actions across diverse phyla and affecting multiple organ systems including the central nervous system. Venom compounds can inhibit or activate ion channels, receptors and transporters with high specificity and affinity providing essential insights into ion channel function. In this review, we focus on arthropod toxins (scorpions, spiders, bees and centipedes) acting on neuronal potassium channels. A brief description of the K+ channels classification and structure is included and a compendium of neuronal K+ channels and the arthropod toxins that modify them have been listed.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.neuropharm.2017.09.025