Nanostructures, concentrations and energies: an ideal equation to extend therapeutic efficiency on radioresistant 9L tumour cells using Ta2O5 ceramic nanostructured particles

Authors

Ryan Brown, University of WollongongFollow
Stephanie Corde, University of WollongongFollow
Sianne Oktaria, University of WollongongFollow
Konstantin K. Konstantinov, University of WollongongFollow
Anatoly B. Rosenfeld, University of WollongongFollow
Michael L. F Lerch, University of WollongongFollow
Moeava Tehei, University of WollongongFollow

RIS ID

111327

Publication Details

Brown, R., Corde, S., Oktaria, S., Konstantinov, K., Rosenfeld, A., Lerch, M. & Tehei, M. (2017). Nanostructures, concentrations and energies: an ideal equation to extend therapeutic efficiency on radioresistant 9L tumour cells using Ta2O5 ceramic nanostructured particles. Biomedical Physics & Engineering Express, 3 (1), 015018-1-015018-13.

Abstract

This work presents an in-depth analysis into the dependencies of radiosensitisation on X-ray beam energy, particle morphology and particle concentration for Ta₂O₅ nanostructured particles. A maximum sensitisation enhancement ratio of 1.46 was attained with irradiation of a 10 MV x-ray photon beam on 9L cells exposed to the less aggregated form of NSPs at 500 μg/mL^-1. A significant increase in sensitisation of 30% was noted at 150 kVp for irradiation of the less aggregated form of tantalum pentoxide NSPs compared to its more agglomerated counterpart. Interestingly, no differences in sensitisation were observed between 50 and 500 μg/mL^-1 for all beam energies and NSPs tested. This is explained by a physical "shell effect", where by the NSPs form layers around the cells (observed using confocal microscopy), with the inner layers contributing to enhancement, while the outer layers shield the cell from damage.

Grant Number

NHMRC/1084994