The present study investigated the time course of visual information processing that is responsible for successful object change detection involving the configuration and shape of 3-D novel object parts. Using a one-shot change detection task, we manipulated stimulus and interstimulus mask durations (40–500 msec). Experiments 1A and 1B showed no change detection advantage for configuration at very short (40-msec) stimulus durations, but the configural advantage did emerge with durations between 80 and 160 msec. In Experiment 2, we showed that, at shorter stimulus durations, the number of parts changing was the best predictor of change detection performance. Finally, in Experiment 3, with a stimulus duration of 160 msec, configuration change detection was found to be highly accurate for each of the mask durations tested, suggesting a fast processing speed for this kind of change information. However, switch and shape change detection reached peak levels of accuracy only when mask durations were increased to 160 and 320 msec, respectively. We conclude that, with very short stimulus exposures, successful object change detection depends primarily on quantitative measures of change. However, with longer stimulus exposures, the qualitative nature of the change becomes progressively more important, resulting in the well-known configural advantage for change detection.