Title
Delayed preattentional functioning in early psychosis patients with cannabis use
Document Type
Journal Article
RIS ID
52030
Abstract
Rationale Cannabis use is prevalent among the early psychosis (EP) population. The event-related potentials, mismatch negativity (MMN) and P3a are reduced in EP. Cannabinoids have been shown to modulate N-methyl-Daspartate receptors which are involved in MMN generation. Objectives This study is the first to investigate the effects of cannabis use on MMN/P3a in EP. Methods EP was defined as a history of psychosis or psychotic symptoms with no progression to date to chronic schizophrenia. Twenty-two EP patients with cannabis use (EP+CANN), 22 non-cannabis-using EP patients (EPCANN) and 21 healthy controls participated in this study. MMN/P3a was elicited using a two-tone, auditory paradigm with 8% duration deviants. Results As expected, EP-CANN showed marked reductions in MMN/P3a amplitudes compared to controls. However, EP+CANN showed evidence of a different pattern of neurophysiological expression of MMN/P3a compared to nonusing patients, most notably in terms of delayed frontal MMN/P3a latencies. Conclusions This study provides further evidence that MMN/P3a deficits are present during early psychosis and suggests that this biomarker may have utility in differentiating substance- from non-substance-related psychoses.
This record is in the process of being updated. Please contact us for more information.
Publication Details
Pesa, N., Hermens, D. F., Battisti, R. A., Kaur, M., Hickie, I. B. & Solowij, N. (2012). Delayed preattentional functioning in early psychosis patients with cannabis use. Psychopharmacology, 222 (3), 507-518.