Title

High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans

RIS ID

36318

Publication Details

O'Neill, B. V., Croft, R. J., Mann, C., Dang, O., Leung, S., Galloway, M. P., Phan, K. L. & Nathan, P. J. (2011). High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans. Journal of Psychopharmacology, 25 (12), 1632-1638.

Abstract

An impaired capacity to filter or ‘gate’ sensory information is a core deficit in cognitive function associated with schizophrenia. These deficits have been linked in part to N-methyl-D-aspartate (NMDA) receptor dysfunction. An association between high levels of glycine, a positive allosteric modulator of the NMDA receptor, and sensorimotor gating impairments (i.e. prepulse inhibition (PPI) deficit) have been reported in animal models of schizophrenia as well as patients with schizophrenia. This study examined the acute effects of modulating the glycine site of the NMDA receptor (with high-dose glycine) on sensory gating as measured by PPI.

Please refer to publisher version or contact your library.

Share

COinS
 

Link to publisher version (DOI)

http://dx.doi.org/10.1177/0269881110372546