High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans

Authors

B V. O'Neill
R J. Croft, University of WollongongFollow
C Mann, Monash University
O Dang
Su Leung
M P. Galloway
K L. Phan, University of Chicago
P J. Nathan, University of Cambridge

RIS ID

36318

Publication Details

O'Neill, B. V., Croft, R. J., Mann, C., Dang, O., Leung, S., Galloway, M. P., Phan, K. L. & Nathan, P. J. (2011). High-dose glycine impairs the prepulse inhibition measure of sensorimotor gating in humans. Journal of Psychopharmacology, 25 (12), 1632-1638.

Abstract

An impaired capacity to filter or ‘gate’ sensory information is a core deficit in cognitive function associated with schizophrenia. These deficits have been linked in part to N-methyl-D-aspartate (NMDA) receptor dysfunction. An association between high levels of glycine, a positive allosteric modulator of the NMDA receptor, and sensorimotor gating impairments (i.e. prepulse inhibition (PPI) deficit) have been reported in animal models of schizophrenia as well as patients with schizophrenia. This study examined the acute effects of modulating the glycine site of the NMDA receptor (with high-dose glycine) on sensory gating as measured by PPI.