Steel-concrete-steel (SCS) sandwich panels are an effective means for protecting personnel and infrastructure facilities from the effects of external blast and high-speed vehicle impact. In conventional SCS construction, the external steel plates are connected to the concrete infill by welded shear stud connectors. This paper describes a programme of research in which the non-composite SCS panels with axially restrained connections were studied experimentally and numerically. High fidelity finite element models for axially restrained SCS panels subjected to impact loading conditions were developed using LS-DYNA. The simulation results were validated against the dynamic testing experimental results. The numerical models were able to predict the initial flexural response of the panels followed by the tensile membrane resistance at large deformation. It was found that the strain rate effects of the materials and the concrete material model could have significant effect on the numerically predicted flexural strength and tensile membrane resistance of the panels.