Gene network analysis and design

Authors

Matthew J. Berryman, University of WollongongFollow
Andrew Allison, University of Adelaide
Derek Abbott, University of AdelaideFollow

RIS ID

42439

Publication Details

Berryman, M. J., Allison, A. Abbott, D. (2005). Gene network analysis and design. Biomedical Applications of Micro- and Nanoengineering (pp. 126-133).

Abstract

Gene networks are composed of many different interacting genes and gene products (RNAs and proteins). They can be thought of as switching regions in n-dimensional space or as mass-balanced signaling networks. Both approaches allow for describing gene networks with the limited quantitative or even qualitative data available. We show how these approaches can be used in modeling the apoptosis gene network that has a vital role in tumor development. The open question is whether engineering changes to this network could be used as a possible cancer treatment.