Title

Gelatin coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study

RIS ID

32947

Publication Details

Gaihre, B., khil, M. S., Lee, D. R. & Kim, H. Y. (2009). Gelatin coated magnetic iron oxide nanoparticles as carrier system: drug loading and in vitro drug release study. International Journal of Pharmaceutics, 365 (1-2), 180-189.

Abstract

Magnetic iron oxide nanoparticles (IOPs) were coated with gelatin A and B and drug-loading efficiency was investigated using doxorubicin (DXR) as a model drug to evaluate their potential as a carrier system for magnetic drug targeting. Drug loading to coated IOPs was done using adsorption as well as desolvation/cross-linking techniques to understand their role. Drug loading by adsorption technique was done by incubating mixture of coated IOPs and drug in various conditions of pH, DXR-to-coated IOPs ratio, gelatin types and IOPs amounts. Drug loading by desolvation/cross-linking technique was done by adding acetone and glutaraldehyde (GTA) to the mixture of coated IOPs and DXR. The results indicated involvement of electrostatic interaction during loading of DXR-to-coated IOPs. Compared to adsorption technique, desolvation/cross-linking technique improved the efficiency of drug loading regardless of type of gelatin used for the coating. The DXR-loaded particles showed pH responsive drug release leading to accelerate release of drug at pH 4 compared to pH 7.4.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.ijpharm.2008.08.020