Investigating the impact of treatment delivery uncertainties on treatment effectiveness for lung SABR

Authors

Samuel J. Blake, University of SydneyFollow
Sankar Arumugam, University of New South WalesFollow
Lois C. Holloway, University of WollongongFollow
Shalini K. Vinod, University of SydneyFollow
Cesar Ochoa, Liverpool and Macarthur Cancer Therapy Centres
Penny Phan, Liverpool and Macarthur Cancer Therapy Centres
Christian R. Hansen, University of Southern Denmark
David Thwaites, University of SydneyFollow

RIS ID

117171

Publication Details

Blake, S. J., Arumugam, S., Holloway, L., Vinod, S., Ochoa, C., Phan, P., Hansen, C. R. & Thwaites, D. I. (2017). Investigating the impact of treatment delivery uncertainties on treatment effectiveness for lung SABR. Australasian Physical and Engineering Sciences in Medicine, 40 (4), 823-829.

Abstract

To quantify the impact of treatment delivery uncertainties on lung stereotactic ablative body radiotherapy (SABR) plans for step-and-shoot intensity-modulated radiotherapy (ssIMRT) and volumetric modulated arc therapy (VMAT). Baseline ssIMRT and VMAT treatment plans were generated for a cohort of 18 lung SABR patients. Modified plans were generated for each baseline plan by systematically varying gantry and collimator angles between - 5 and + 5 degrees, as well as multi-leaf collimator (MLC) leaf position errors of magnitude between 1 and 5 mm in both directions (i.e. leaf banks shifted either in the same (Type 1) or opposite (Type 2) directions). Planning target volume (PTV), spinal cord and healthy lung dose-volume histogram (DVH) metrics were compared between the modified and baseline plans.