Title

Investigating the impact of treatment delivery uncertainties on treatment effectiveness for lung SABR

RIS ID

117171

Publication Details

Blake, S. J., Arumugam, S., Holloway, L., Vinod, S., Ochoa, C., Phan, P., Hansen, C. R. & Thwaites, D. I. (2017). Investigating the impact of treatment delivery uncertainties on treatment effectiveness for lung SABR. Australasian Physical and Engineering Sciences in Medicine, 40 (4), 823-829.

Abstract

To quantify the impact of treatment delivery uncertainties on lung stereotactic ablative body radiotherapy (SABR) plans for step-and-shoot intensity-modulated radiotherapy (ssIMRT) and volumetric modulated arc therapy (VMAT). Baseline ssIMRT and VMAT treatment plans were generated for a cohort of 18 lung SABR patients. Modified plans were generated for each baseline plan by systematically varying gantry and collimator angles between - 5 and + 5 degrees, as well as multi-leaf collimator (MLC) leaf position errors of magnitude between 1 and 5 mm in both directions (i.e. leaf banks shifted either in the same (Type 1) or opposite (Type 2) directions). Planning target volume (PTV), spinal cord and healthy lung dose-volume histogram (DVH) metrics were compared between the modified and baseline plans.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s13246-017-0591-x