This work addresses a novel computer-aided diagnosis (CAD) system in breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI). The CAD system is designed based on a mixture ensemble of convolutional neural networks (ME-CNN) to discriminate between benign and malignant breast tumors. The ME-CNN is a modular and image-based ensemble, which can stochastically partition the high-dimensional image space through simultaneous and competitive learning of its modules. The proposed system was assessed on our database of 112 DCE-MRI studies including solid breast masses, using a wide range of classification measures. The ME-CNN model composed of three CNN experts and one convolutional gating network achieves an accuracy of 96.39%, a sensitivity of 97.73% and a specificity of 94.87%. The experimental results also show that it has competitive classification performances compared to three existing single-classifier methods and two convolutional ensemble methods. The proposed ME-CNN model could provide an effective tool for radiologists to analyse breast DCE-MRI images.
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