Title

Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate

RIS ID

79276

Publication Details

Zhang, Y., Sun, Y., Xu, X., Zhu, H., Huang, L., Zhang, X., Qi, Y. & Shen, Y. (2010). Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly(amido)-amine folic acid conjugate. Bioorganic and Medicinal Chemistry Letters, 20 (3), 927-931.

Abstract

Acetylated (Ac) dendrimer poly(amido)-amine (PAMAM) generation 5 (G5) reacted with folic acid (FA), followed by reacting with 2-(p-isothiocyanatobenzyl)-6-methyl-diethylenetria minepentaacetic acid (1B4M DTPA) to form the conjugate of Ac-G5-FA-1B4M DTPA which was further radiolabeled with 99mTc. The radiochemical yield is up to 98.9% with excellent in vitro/in vivo stability, rapid blood clearance and certain tumor accumulation which was further confirmed by micro-SPECT imaging study.

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Link to publisher version (DOI)

http://dx.doi.org/10.1016/j.bmcl.2009.12.075