An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates

Authors

Martin Carolan, University of WollongongFollow
Bradley Oborn, University of WollongongFollow
Kerwyn Foo, Royal Prince Alfred HospitalFollow
Annette Haworth, Peter Mccallum Cancer Centre
Sarah Gulliford, Institute Of Cancer Research And Royal Marsden National Health Service Foundation Trust, Uk
Martin A. Ebert, University of Wollongong

RIS ID

88794

Publication Details

Carolan, M., Oborn, B., Foo, K., Haworth, A., Gulliford, S. & Ebert, M. A. (2014). An MLE method for finding LKB NTCP model parameters using Monte Carlo uncertainty estimates. Journal of Physics: Conference Series, 489 012087-1-012087-6.

Abstract

The aims of this work were to establish a program to fit NTCP models to clinical data with multiple toxicity endpoints, to test the method using a realistic test dataset, to compare three methods for estimating confidence intervals for the fitted parameters and to characterise the speed and performance of the program.