Radiation dose and contralateral breast cancer risk associated with megavoltage cone-beam computed tomographic image verification in breast radiation therapy

Authors

Alexandra Quinn, University of WollongongFollow
Lois Holloway, University of WollongongFollow
Eng-Siew Koh, Liverpool and Macarthur Cancer Therapy Centres
Geoff Delaney, Liverpool and Macarthur Cancer Therapy Centres
Sankar Arumugam, Liverpool and Macarthur Cancer Therapy Centres
Gary Goozee, Liverpool and Macarthur Cancer Therapy Centres
Peter E. Metcalfe, University of WollongongFollow

RIS ID

77134

Publication Details

Quinn, A., Holloway, L., Koh, E., Delaney, G., Arumugam, S., Goozee, G. & Metcalfe, P. (2013). Radiation dose and contralateral breast cancer risk associated with megavoltage cone-beam computed tomographic image verification in breast radiation therapy. Practical Radiation Oncology, 3 (2), 93-100.

Abstract

Purpose: To measure and compare organ doses from a standard tangential breast radiation therapy treatment (50 Gy delivered in 25 fractions) and a megavoltage cone-beam computed tomography (MV-CBCT), taken for weekly image verification, and assess the risk of radiation-induced contralateral breast cancer. Methods and Materials: Organ doses were measured with thermoluminescent dosimeters placed strategically within a female anthropomorphic phantom. The risk of radiation-induced secondary cancer of the contralateral breast was estimated from these values using excess absolute risk and excess relative risk models.