Title

Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels

RIS ID

82600

Publication Details

Al Garalleh, H., Thamwattana, N., Cox, B. J. & Hill, J. M. (2013). Modelling carbon dioxide molecule interacting with aquaglyceroporin and aquaporin-1 channels. Journal of Mathematical Chemistry, 51 (9), 2317-2327.

Abstract

Aquaporin (AQP) is a family of membrane proteins that enable water and small individual molecules to permeate cell membranes. Examples of these protein channels are aquaglyceroporin and aquaporin-1 (AQP1). Here, we investigate the permeability of carbon dioxide (CO2) through both aquglyceroporin and AQP1 channels and explain their selectivity mechanisms. We provide a mathematical model which determines the molecular interaction potential between carbon dioxide molecule and an AQP channel. We evaluate this interaction using two approaches, namely discrete-continuum and completed discrete approaches. Both calculations agree well and our results indicate the acceptance of (CO2) molecule into these channels which is in good agreement with other recent studies. 2013 Springer Science+Business Media New York.

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Link to publisher version (DOI)

http://dx.doi.org/10.1007/s10910-013-0240-x